Evolución de la leucemia linfoblástica aguda en la edad pediátrica en 29 años ( )Outcome of acute lymphoblastic leukemia in the pediatric age group . La leucemia linfoblástica aguda (LLA) es el cáncer más común en los niños y está entre los más curables de las malignidades pediátricas. El análisis citogenético de las células blásticas en niños con leucemia linfoblástica aguda (LLA) ha permitido el reconocimiento de alteraciones cromosómicas.

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Leucemia linfoblástica aguda en pacientes portadores de síndrome de Down

Estos pacientes pueden ser tratados con los protocolos actuales pero requieren un manejo precoz e intensivo de las infecciones. These patients can be treated with the current trials but they require a detailed infection care.

A Pediatric Oncology Group Study. Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization. Translocation 12;22 p13;q11 in myeloproliferative disorders results in fusion of the ETS-like Tel gene on 12p13 to the MN1 gene on 22q Cytogenetic and molecular studies of Down syndrome individuals with leukemia.


Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Large-scale molecular mapping of human c-myb: Heterogeneity of presenting features and their relation to treatment outcome in clildren with T-cell acute lymphoblastic leukemia.

Blood ; Fusion with EA2 converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the 1; Am J Med Genet Suppl ; 7: Br J Haematol,pp.

Favorable prognosis of hyperdiploid common acute lymphoblastic leukemia may be explained by sensitivity to antimetabolites and other drugs: J Pediatr Hematol Oncol ; Down’s syndrome linnfoblastica childhood acute lymphoblastic leukemia: Current status of cytogenetic research in childhood acute lymphoblastic leukemia.

Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome.

Genomics, 17pp. N Engl J Med,pp. Br Med J, 2pp. Epub Sep Clinical data, immunophenotype, cytogenetics and treatment results were analyzed. Br J Haematol, 90pp.

Pediatr Blood Cancer leicemia Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t 1;9 q23;p13 or its derivative. Lippincott Williams and Wilkins, ; Insights into the manifestations, outcomes, and mechanisms of leuke mogenesis in Down syndrome. Pediatr Clin North Am ; Blood, 65pp.


Factores de riesgo para la leucemia linfocítica aguda

Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure. Blood, 84pp. Blood and Cancer ; The management of patients with leukemia: Localization the estrogen receptor locus ESR to chromosome 6q Increased incidence of spontaneus apoptosis in the bone marrow of hyperdiploid chilhood acute lymphoblastic leukemia.

Leukemia ; 12 5: Immunology of Down syndrome.

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