Download scientific diagram | – Cnidoscolus quercifolius plant. from publication: Análise Química e Bromatológica da Forragem da Faveleira (Cnidoscolus. PDF | Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential. The Cnidoscolus quercifolius (Pohl) popularly known as “favela” or “faveleira” is a forager that is part of the native species from the caatinga.

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Almeida [ 43 ] performed an antimicrobial assay with strains of bacteria and fungi using hydroalcoholic extract of the leaves of C. Table 2 shows the results of antimicrobial activity of methanolic extracts of C. View at Google Scholar S.

View at Google Scholar I.

This study did not detect alkaloids in any of the C. View at Google Scholar R.

With the aid of a light source, the hatched larvae were attracted to the lightened vessel part and were collected with a Pasteur pipette and then transferred to a beaker with saline water. In the bark of C. The semiarid region of the Brazilian Northeast is known for hosting a number of native species that are under systematic exploitation in recent years, without any sustainable management, which ultimately causes the extinction of some species, thus unleashing a rural exodus.

Its xerophile character allows the plant to grow and reproduce, even in periods of prolonged droughts, thus contributing to keep the balance of the ecosystem, mitigating environmental degradation.

Evidence-Based Complementary and Alternative Medicine

The extracts were subjected to phytochemical screening, following the protocols described by Mattos [ 16 ]. Result of inhibition of the acetylcholinesterase enzyme from methanolic extracts of C.

The excess of oxidative stress which leads to organic decay is mitigated or even prevented by antioxidants-based therapies. Evidence-Based Complementary and Alternative Medicine. The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, as previously reported by Brand-Williams et al.

Cnidoscolus quercifolius – Useful Tropical Plants

The identification of these plants, through phytochemical and ethnopharmacological studies, provides the possibility of discovery and development of new drugs that could be relevant for the treatment of degenerative diseases of the nervous system, through the effect of AChE inhibition [ 4950 ]. The analysis of nuclear magnetic spectra of the active chloroform fraction revealed the presence of absorptions bands correspondent to a mixture of favelines such as neofavelanone, deoxofaveline or methyl-faveline, which structures were confirmed by ultraviolet spectra upon high-performance liquid chromatography with diode-array detection analysis.


Studies conducted by Almeida and Amorim [ 36 ] showed that the methanolic extract of the root of C. Despite the negative presence of alkaloids in the faveleira extracts tested, the plant presented satisfactory activity of enzyme inhibition, when compared with the reference substance, raising the possibility that new untested substances may act on the inhibition of AChE.

It was the start of a series of cultural intermixes that blended the knowledge brought in by the colonizers, the slaves, and the natives. It stands out for its extraordinary drought resistance and medicinal properties. None, Conflict of Interest: The objective of this study was to assess the therapeutic potential of compounds extracted from Cnidoscolus quercifolius Pohl in preventing disease and its rational use as a herbal therapeutic tool.

By agar diffusion method, the LME and the RBME showed similar activity by inhibiting the growth of Enterococcus faeciumEnterococcus faecalisStaphylococcus epidermidisand Pseudomonas aeruginosawhile the RME inhibited only the strain of Staphylococcus epidermidis.

To analyze the significance of the differences between the samples the authors used Variance Analysis ANOVA followed by the Newman-Keuls comparison test, being considered significant. The high-performance liquid chromatography with diode-array detection and 1 H and 13 C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract. The in vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF, HCT, HL strains and the samples were assessed by 3- 4,5-dimethylthiazol2-yl -2,5-diphenyltetrazolium bromide method.

Preliminary phytochemical analysis of C. This is a different outcome from the findings of this study, for none of the methanolic extracts of the faveleira exhibited growth inhibition of fungi of the same family. The results demonstrated great potential as an antimicrobial agent, an important antioxidant capacity, and acetylcholinesterase inhibition response with no significant difference compared with the reference drug.


Hoffm presented relevant antioxidant activity and phenolic compounds in the species, suggesting that C. Oxidative stress may occur when there is limitation in the availability of antioxidants.

View at Google Scholar C. Assays were performed in triplicate, and the number of dead larvae was counted after 24 hours.

However, other species of the genus Cnidoscolus showed the presence of alkaloids [ 28 — 30 ]. As far as we know, there cnidoscolks no data in the literature showing the antioxidant activity of samples of C. Studies have shown that plants used in traditional medicine have the effect of prevention and protection under conditions of oxidative stress [ 38 — 40 ].

In the analysis of the leaves of C. The caatingaan exclusively Brazilian biome, is one of the most endangered vegetation systems in the planet. Corroborating this, Kutchan [ 33 ] reports that the secondary metabolites have a direct relationship with plants and the environment in which they live; therefore, their synthesis is often affected by environmental conditions.

The determination of the Minimum Inhibitory Concentration of Fungi MIC-f was obtained with a stereoscope, verifying the lower concentration of samples capable of inhibiting the growth of the microorganism, after 5 days of incubation. It is widely used as qiercifolius for cattle and small ruminants, mainly in the dry periods.

Da Planta ao MedicamentoC.

Cnidoscolus quercifolius

Moreover, other factors such as seasonality, circadian rhythm, development, climatic factors, water availability, ultraviolet radiation, nutrients, air pollution, and altitude may influence the composition of the secondary metabolites of plants [ 32 ]. The present study, of crude methanolic extracts of Cnidoscolus quercifolius Pohl, has shown promising results in all tests performed. In many cases, the procedures of modern medicine and popular medicine are supplemental and constitute an effective form of primary health care, which may supplement the treatment usually employed in the lower income population.

View at Google Scholar L.

The inhibition was indicated by the presence of white halos.

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